Known For: Being a slave turned social activistĭred Scott was a slave for several owners before he tried to sue for his freedom in a Missouri Court. Below is a list of some of the most famous African-Americans of all time. Their remarkable efforts and achievements, and life stories are often are quite worthy of high recognition. Throughout history many famous African-American men and women have contributed significantly to society as far as civil rights, music, science, sports, equality are concerned.